Alan P Kozikowski Selected Research

Histone Deacetylase 6

1/2021	Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
2/2020	A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019).
1/2020	Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.
1/2019	Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
1/2019	Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
1/2018	HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
10/2017	Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.
2/2016	Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease.
1/2014	A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.
11/2013	A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Alan P Kozikowski Research Topics

Disease

31	Neoplasms (Cancer) 01/2020 - 04/2002
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 02/2006
9	Tuberculosis (Tuberculoses) 01/2013 - 10/2008
8	Pancreatic Neoplasms (Pancreatic Cancer) 07/2021 - 03/2008
8	Alzheimer Disease (Alzheimer's Disease) 06/2011 - 01/2003
7	Schizophrenia (Dementia Praecox) 10/2017 - 05/2004
7	Prostatic Neoplasms (Prostate Cancer) 07/2014 - 04/2002
5	Extensively Drug-Resistant Tuberculosis 05/2020 - 04/2009
5	Infections 01/2017 - 10/2009
5	Cocaine-Related Disorders (Cocaine Addiction) 08/2005 - 07/2002
4	Melanoma (Melanoma, Malignant) 01/2020 - 11/2012
4	Traumatic Brain Injuries (Traumatic Brain Injury) 08/2008 - 03/2003
3	Mental Disorders (Mental Disorder) 05/2020 - 02/2008
3	Central Nervous System Diseases (CNS Diseases) 10/2014 - 11/2004
3	Bipolar Disorder (Manic Depressive Psychosis) 09/2011 - 02/2006
3	Coinfection 01/2011 - 10/2009
3	Hypoxia (Hypoxemia) 04/2010 - 09/2002
3	Nervous System Diseases (Neurological Disorders) 12/2008 - 06/2004
2	Fragile X Syndrome (Martin Bell Syndrome) 01/2021 - 01/2019
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 01/2018
2	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2018 - 02/2016
2	Obesity 10/2017 - 12/2015
2	Catalepsy 10/2017 - 01/2016
2	Substance-Related Disorders (Drug Abuse) 12/2015 - 02/2006
2	Seizures (Absence Seizure) 03/2013 - 09/2008
2	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2012 - 05/2009
2	Mania (Manias) 09/2011 - 07/2007
2	Cognitive Dysfunction 06/2011 - 07/2004
2	Neglected Diseases 10/2009 - 02/2008
2	Inflammation (Inflammations) 05/2007 - 12/2004
2	Pain (Aches) 05/2007 - 03/2004
2	Carcinogenesis 05/2005 - 04/2003
1	Type 2A Charcot-Marie-Tooth disease 01/2021
1	Rare Diseases (Rare Disease) 01/2019
1	Neurobehavioral Manifestations 10/2017
1	Weight Loss (Weight Reduction) 10/2017

Drug/Important Bio-Agent (IBA)

22	Pharmaceutical PreparationsIBA 05/2020 - 08/2002
13	LigandsIBA 02/2020 - 01/2003
11	Histone Deacetylase 6IBA 01/2021 - 11/2012
8	Histone Deacetylase InhibitorsIBA 10/2017 - 05/2005
7	Proteins (Proteins, Gene)FDA Link 01/2016 - 02/2003
6	Histone Deacetylases (Histone Deacetylase)IBA 10/2017 - 03/2008
5	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 12/2008 - 04/2002
4	Glycogen Synthase (Synthase I)IBA 07/2021 - 07/2007
4	Biological ProductsIBA 11/2009 - 01/2003
4	Ether (Diethyl Ether)IBA 09/2007 - 02/2003
4	Phosphatidylinositols (Phosphatidylinositol)IBA 09/2007 - 02/2003
4	LipidsIBA 09/2007 - 02/2003
3	TubulinIBA 05/2020 - 01/2018
3	Glycogen Synthase Kinase 3IBA 11/2019 - 01/2012
3	Glycogen Synthase KinasesIBA 11/2019 - 04/2009
3	Protein Isoforms (Isoforms)IBA 10/2017 - 06/2009
3	Serotonin (5 Hydroxytryptamine)IBA 10/2017 - 06/2004
3	Rad51 RecombinaseIBA 11/2016 - 01/2013
3	EnzymesIBA 01/2016 - 07/2007
3	AntigensIBA 12/2012 - 06/2005
3	Urea (Carbamide)FDA LinkGeneric 11/2012 - 03/2004
3	Therapeutic UsesIBA 06/2011 - 07/2004
3	Glycogen Synthase Kinase 3 betaIBA 04/2009 - 02/2006
3	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 02/2006 - 09/2002
3	Cocaine (Cocaine HCl)IBA 08/2005 - 07/2002
2	SW-100IBA 01/2021 - 01/2019
2	Phosphotransferases (Kinase)IBA 11/2019 - 02/2003
2	Small Interfering RNA (siRNA)IBA 11/2019 - 01/2012
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2017 - 01/2008
2	Mycolic Acids (Mycolic Acid)IBA 01/2017 - 01/2013
2	DNA (Deoxyribonucleic Acid)IBA 11/2016 - 07/2014
2	Neuroprotective AgentsIBA 01/2014 - 03/2003
2	Histones (Histone)IBA 01/2014 - 08/2008
2	maleimideIBA 06/2013 - 01/2012
2	LithiumIBA 06/2013 - 07/2007
2	Membrane Proteins (Integral Membrane Proteins)IBA 12/2012 - 06/2005
2	huperzine AIBA 06/2011 - 09/2008
2	EstersIBA 10/2010 - 09/2003
2	AcidsIBA 10/2010 - 01/2006
2	AmidesIBA 02/2010 - 09/2003
2	RadiopharmaceuticalsIBA 05/2008 - 06/2005
2	Phencyclidine (Angel Dust)IBA 01/2008 - 05/2004
2	Protein Kinase CIBA 03/2006 - 09/2003
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 03/2006 - 01/2003
2	Hormones (Hormone)IBA 06/2005 - 09/2003
2	DiketopiperazinesIBA 03/2003 - 03/2003
2	1-ARA-35bIBA 03/2003 - 03/2003
2	DipeptidesIBA 03/2003 - 03/2003
1	1,2,3,4-tetrahydroquinolineIBA 01/2021
1	OxadiazolesIBA 02/2020
1	Gemcitabine FDA Link 11/2019
1	Aurora KinasesIBA 04/2019
1	Protein Kinase InhibitorsIBA 04/2019
1	Glycine-tRNA LigaseIBA 01/2018
1	4- ((1- butyl- 3- phenylureido)methyl)- N- hydroxybenzamideIBA 10/2017
1	Amphetamine (Amfetamine)FDA LinkGeneric 10/2017
1	lorcaserinIBA 10/2017
1	Serotonin 5-HT2 Receptor AgonistsIBA 10/2017
1	Dopamine (Intropin)FDA LinkGeneric 10/2017
1	Antipsychotic Agents (Antipsychotics)IBA 10/2017

Therapy/Procedure

19	Therapeutics 01/2019 - 02/2003
4	Drug Therapy (Chemotherapy) 07/2021 - 01/2017
1	Immunotherapy 01/2020
1	Transplantation 01/2017